Ascl1 controls the number and distribution of astrocytes and oligodendrocytes in the gray matter and white matter of the spinal cord.

@article{Vue2014Ascl1CT,
  title={Ascl1 controls the number and distribution of astrocytes and oligodendrocytes in the gray matter and white matter of the spinal cord.},
  author={Tou Yia Vue and Euiseok J. Kim and Carlos M. Parras and François Guillemot and Jane E Johnson},
  journal={Development},
  year={2014},
  volume={141 19},
  pages={3721-31}
}
Glia constitute the majority of cells in the mammalian central nervous system and are crucial for neurological function. However, there is an incomplete understanding of the molecular control of glial cell development. We find that the transcription factor Ascl1 (Mash1), which is best known for its role in neurogenesis, also functions in both astrocyte and oligodendrocyte lineages arising in the mouse spinal cord at late embryonic stages. Clonal fate mapping in vivo reveals heterogeneity in… CONTINUE READING