Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo.

@article{Liu2015Ascl1CD,
  title={Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo.},
  author={Yueguang Liu and Qinglong Miao and Jiacheng Yuan and Su'e Han and Panpan Zhang and Sanlan Li and Zhiping Rao and Wenlong Zhao and Qiao Ye and Junlan Geng and Xiaohui Zhang and Leping Cheng},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 25},
  pages={9336-55}
}
In vivo induction of non-neuronal cells into neurons by transcription factors offers potential therapeutic approaches for neural regeneration. Although generation of induced neuronal (iN) cells in vitro and in vivo has been reported, whether iN cells can be fully integrated into existing circuits remains unclear. Here we show that expression of achaete-scute complex homolog-like 1 (Ascl1) alone is sufficient to convert dorsal midbrain astrocytes of mice into functional iN cells in vitro and in… CONTINUE READING