Ascending impairment of nociception in rats with experimental allergic encephalomyelitis.

@article{Pender1986AscendingIO,
  title={Ascending impairment of nociception in rats with experimental allergic encephalomyelitis.},
  author={Michael P. Pender},
  journal={Journal of the neurological sciences},
  year={1986},
  volume={75 3},
  pages={317-28}
}
An ascending impairment of tail nociception is a previously undescribed clinical sign of acute experimental allergic encephalomyelitis (EAE) in the rat. It occurs in EAE induced by inoculation with purified central nervous system (CNS) myelin basic protein (MBP) as well as with whole spinal cord. It is invariably present and consists of an absence of the vocalization response to noxious mechanical stimulation of the tail. This impairment of nociception evolves over 1-3 days, simultaneously with… CONTINUE READING
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