Ascending aorta dilation in association with bicuspid aortic valve: a maturation defect of the aortic wall.

@article{Grewal2014AscendingAD,
  title={Ascending aorta dilation in association with bicuspid aortic valve: a maturation defect of the aortic wall.},
  author={Nimrat Grewal and Adriana C. Gittenberger-de Groot and Robert E. Poelmann and Robert J. M. Klautz and Johannes H. N. Lindeman and Marie Jose T. H. Goumans and Meindert Palmen and Salah Ali Mohamed and H H Sievers and Ad J. J. C. Bogers and Marco C DeRuiter},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2014},
  volume={148 4},
  pages={1583-90}
}
OBJECTIVE Patients with a bicuspid aortic valve have increased susceptibility to the development of ascending aortic dilation and dissection compared with persons with a tricuspid valve. To unravel a possible different mechanism underlying dilation in bicuspidy and tricuspidy, a comparison of the structure of the aortic wall was made. METHODS Ascending aortic wall biopsies were divided into 4 groups: bicuspid (n=36) and tricuspid (n=23) without and with dilation. The expression of vascular… CONTINUE READING

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