Ascending aorta dilatation in patients with bicuspid aortic valve stenosis: a prospective CMR study


The aim of this study was to evaluate the natural progression of aortic dilatation and its association with aortic valve stenosis (AoS) in patients with bicuspid aortic valve (BAV). Prospective study of aorta dilatation in patients with BAV and AoS using cardiac magnetic resonance (CMR). Aortic root, ascending aorta, aortic peak velocity, left ventricular systolic and diastolic function and mass were assessed at baseline and at 3-year follow-up. Of the 33 enrolled patients, 5 needed surgery, while 28 patients (17 male; mean age: 31 ± 8 years) completed the study. Aortic diameters significantly increased at the aortic annulus, sinus of Valsalva and tubular ascending aorta levels (P < 0.050). The number of patients with dilated tubular ascending aortas increased from 32 % to 43 %. No significant increase in sino-tubular junction diameter was observed. Aortic peak velocity, ejection fraction and myocardial mass significantly increased while the early/late filling ratio significantly decreased at follow-up (P < 0.050). The progression rate of the ascending aorta diameter correlated weakly with the aortic peak velocity at baseline (R 2 = 0.16, P = 0.040). BAV patients with AoS showed a progressive increase of aortic diameters with maximal expression at the level of the tubular ascending aorta. The progression of aortic dilatation correlated weakly with the severity of AoS. • Bicuspid aortic valve (BAV) is the most common congenital heart defect. • BAV patients have an increased risk of developing aortic valve stenosis (AoS). • BAV patients have an increased risk of developing thoracic aorta dilatation. • The severity of aortic stenosis is correlated to the progression of aortic dilatation. • Cardiac magnetic resonance can rapidly assess patients with a bicuspid aortic valve.

DOI: 10.1007/s00330-012-2651-7

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@article{Rossi2012AscendingAD, title={Ascending aorta dilatation in patients with bicuspid aortic valve stenosis: a prospective CMR study}, author={A. Rossi and Denise van der Linde and Sing Chien Yap and Thomas Lapinskas and Sharon W. Kirschbaum and Tirza Springeling and Maarten Witsenburg and Judith Anne Adriane Ellen Cuypers and Adriaan Moelker and Gabriel P. Krestin and A. C. van Dijk and Mark R. D. Johnson and Robert-Jan M. van Geuns and Jolien W Roos-Hesselink}, journal={European Radiology}, year={2012}, volume={23}, pages={642-649} }