Ascaris suum: human lymphocyte mitogenic factor content.

  title={Ascaris suum: human lymphocyte mitogenic factor content.},
  author={Shin-ichi Sasagawa and Kunio Suzuki and Tomoyuki Fujikura},
  journal={Experimental parasitology},
  volume={64 1},
Ascaris suum extract was found to contain a mitogenic factor which stimulates human lymphocytes. The extract (100 micrograms protein/ml) induced an increase in [3H]thymidine incorporation into human lymphocytes at a level similar to that obtained with pokeweed mitogen (11 micrograms/ml). Stimulation of mitosis appeared to be more effective with T lymphocytes than non-T lymphocytes. The mitogenic activity of the extract was reduced by only 27% when treated at 56 C for 30 min or when immersed… CONTINUE READING