Ascaris lumbricoides: an overview of therapeutic targets.

  title={Ascaris lumbricoides: an overview of therapeutic targets.},
  author={Isabel Hagel and Tatiana Giusti},
  journal={Infectious disorders drug targets},
  volume={10 5},
A. lumbricoides is the largest of the common nematode parasites of man and has been associated with intestinal pathology, respiratory symptoms and malnutrition in children from endemic areas. Current anthelmintic treatments have proven to be safe. However, a reduced efficacy of single dose drugs has been reported. In veterinary practice, anthelmintic drug resistance is an irreversible problem. Thus, research and development of sensitive tools for early detection of drug resistance as well as… 

Ascaris lumbricoides β carbonic anhydrase: a potential target enzyme for treatment of ascariasis

Functional predictions suggest that AIBCA might play a role in bicarbonate-mediated metabolic pathways, such as gluconeogenesis and removal of metabolically produced cyanate, and suggest that novel β-CA specific inhibitors should be developed and tested against helminthic diseases.

Soil-Transmitted Helminth Vaccines: Are We Getting Closer?

Current knowledge in lead antigen identification and reports on recent pre-clinical and clinical trials in the context of soil-transmitted helminths Trichuris, the hookworms and Ascaris are explored, suggesting a multivalent anthelminthic vaccine could become an essential tool for achieving the medium-to long-term goal of controlling, or even eliminating helminth infections.

Haemonchosis in Sheep and Goats, Control Strategies and Development of Vaccines against Haemonchus contortus

This review highlights the current state of knowledge on anti-H.


More research on the mechanisms of resistance to infection is required for reducing prevalence parasite and control of infections.

Burdens of Ascaris spp. and Cryptosporidium spp. parasites in farm pigs in Ghana

The high burden of Ascaris and Cryptosporidium infections in the pigs suggest the need to adopt and implement effective control measures.

Parasites in Paraguay: An Analysis of the Presentation and Management of Intestinal Parasites by Short-Term Medical Mission Volunteers in Paraguay

This analysis identified variance in intestinal parasite presentation and management by age, gender, and location and tended toward treating newly diagnosed clinical disease, as opposed to broad prophylactic administration of antiparasitic medication to at-risk populations.

Marine Natural Products with Bioactivity Against Neglected Tropical Diseases

A review of secondary metabolites isolated from marine sources that have demonstrated activity against neglected tropical diseases and are promising candidates for drug development discusses 114 marine derived metabolites active against the WHO's 2017 list of 20 NTDs.

Infectious helminth ova in wastewater and sludge: A review on public health issues and current quantification practices.

  • P. Gyawali
  • Biology
    Water science and technology : a journal of the International Association on Water Pollution Research
  • 2018
Identifying specific genetic markers including protein, lipid, and metabolites using multiomics approach could be utilized for cheap, rapid, sensitive, specific and point of care detection tools for helminth ova and larva in the wastewater.



A new class of anthelmintics effective against drug-resistant nematodes

The discovery of the amino-acetonitrile derivatives (AADs) as a new chemical class of synthetic anthelmintics and the development of drug candidates that are efficacious against various species of livestock-pathogenic nematodes are described.

Tribendimidine and Albendazole for Treating Soil-Transmitted Helminths, Strongyloides stercoralis and Taenia spp.: Open-Label Randomized Trial

It is suggested that single-dose oral tribendimidine can be employed in settings with extensive intestinal polyparasitism, and its efficacy against A. lumbricoides and hookworm was confirmed.

The New Anthelmintic Tribendimidine is an L-type (Levamisole and Pyrantel) Nicotinic Acetylcholine Receptor Agonist

T tribendimidine may not be a viable anthelmintic where resistance to levamisole or pyrantel already exists but could productively be usedWhere resistance to benzimidazoles exists or could be combined with this class of anthel Mintics.

Anthelmintic activity of paraherquamide in sheep.

The adult stage of Oesophagostomum columbianum was the dosage-limiting parasite with 79% efficacy recorded at the highest treatment level (2.0 mg/kg), which suggests a different mode of action for paraherquamide relative to ivermectin and the benzimidazoles.

Hookworm vaccines: past, present, and future.

Parasitic helminths: a pharmacopeia of anti-inflammatory molecules

The range of immunomodulatory molecules in selected parasitic trematodes, cestodes and nematodes, their impact on the immune cells in the host and how the host may recognize these molecules are illustrated.

Nitazoxanide in the treatment of Ascaris lumbricoides in a rural zone of Colima, Mexico

The most intense infections for A. lumbricoides were found in housewives, and statistically significant associations were found between ascariasis and the absence of drainage and living in houses with dirt floors.

Epidemiology and control of intestinal parasites with nitazoxanide in children in Mexico.

Nitazoxanide was very well tolerated, with no serious adverse effects reported, in the treatment of mixed parasite infections with both intestinal protozoa and helminths in children.

The biochemical basis of anthelmintic action and resistance.

  • P. Köhler
  • Biology
    International journal for parasitology
  • 2001

Efficacy of two cyclooctadepsipeptides, PF1022A and emodepside, against anthelmintic-resistant nematodes in sheep and cattle

Both, PF1022A and emodepside were found to be fully effective against these parasite populations and confirm that this new class of compounds acts by a different mode of action compared to the above-mentioned anthelmintics.