Asbestos-related malignant mesothelioma: growth, cytology, tumorigenicity and consistent chromosome findings in cell lines from five patients.

@article{PelinEnlund1990AsbestosrelatedMM,
  title={Asbestos-related malignant mesothelioma: growth, cytology, tumorigenicity and consistent chromosome findings in cell lines from five patients.},
  author={K Pelin-Enlund and Kirsti Husgafvel-Pursiainen and Lauri Tammilehto and Matti Klockars and K Jantunen and Brenda I. Gerwin and Curtis C. Harris and Tiinamaija Tuomi and Esa Vanhala and K Hammond JS Mattson},
  journal={Carcinogenesis},
  year={1990},
  volume={11 4},
  pages={673-81}
}
Seven mesothelioma cell lines were established from clinical specimens from five patients with asbestos-related malignant pleural mesothelioma. The cells in culture show either epithelial or mixed epithelial/fibrosarcomatous growth with an average doubling time of 30 h. Giant multinucleated cells are common in all the cell lines, as well as long thin microvilli on the cell surfaces. All cell lines were cytokeratin positive and they stained negatively for monocyte-macrophage markers. All seven… CONTINUE READING