Asbestos induces mitochondrial DNA damage and dysfunction linked to the development of apoptosis.

Abstract

To test the hypothesis that asbestos-mediated cell injury is mediated through an oxidant-dependent mitochondrial pathway, isolated mesothelial cells were examined for mitochondrial DNA damage as determined by quantitative PCR. Mitochondrial DNA damage occurred at fourfold lower concentrations of crocidolite asbestos compared with concentrations required for… (More)

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@article{Shukla2003AsbestosIM, title={Asbestos induces mitochondrial DNA damage and dysfunction linked to the development of apoptosis.}, author={Arti Shukla and Michael Jung and Maria Stern and Naomi K. Fukagawa and Douglas J Taatjes and Dennis E Sawyer and Bennett van Houten and Brooke T. Mossman}, journal={American journal of physiology. Lung cellular and molecular physiology}, year={2003}, volume={285 5}, pages={L1018-25} }