Asbestos-induced pulmonary toxicity: role of DNA damage and apoptosis.

@article{Upadhyay2003AsbestosinducedPT,
  title={Asbestos-induced pulmonary toxicity: role of DNA damage and apoptosis.},
  author={Devendra Upadhyay and David William Kamp},
  journal={Experimental biology and medicine},
  year={2003},
  volume={228 6},
  pages={
          650-9
        }
}
Asbestos causes asbestosis and various malignancies by mechanisms that are not clearly defined. Here, we review the accumulating evidence showing that asbestos is directly genotoxic by inducing DNA strand breaks (DNA-SB) and apoptosis in relevant lung target cells. Although the exact mechanisms by which asbestos causes DNA damage and apoptosis are not firmly established, some of the implicated mechanisms include the generation of iron-derived reactive oxygen species (ROS) as well as reactive… CONTINUE READING
BETA
Tweets
This paper has been referenced on Twitter 5 times. VIEW TWEETS

Citations

Publications citing this paper.
SHOWING 1-10 OF 43 CITATIONS

Similar Papers

Loading similar papers…