Asbestos-induced phosphorylation of epidermal growth factor receptor is linked to c-fos and apoptosis.

@article{Zanella1999AsbestosinducedPO,
  title={Asbestos-induced phosphorylation of epidermal growth factor receptor is linked to c-fos and apoptosis.},
  author={Cristiano Zanella and Cynthia R. Timblin and Alex Cummins and M Jung and Jonathan Goldberg and Rodney Raabe and Thomas R. Tritton and Brooke T. Mossman},
  journal={The American journal of physiology},
  year={1999},
  volume={277 4},
  pages={
          L684-93
        }
}
We examined the mechanisms of interaction of crocidolite asbestos fibers with the epidermal growth factor (EGF) receptor (EGFR) and the role of the EGFR-extracellular signal-regulated kinase (ERK) signaling pathway in early-response protooncogene (c-fos/c-jun) expression and apoptosis induced by asbestos in rat pleural mesothelial (RPM) cells. Asbestos fibers, but not the nonfibrous analog riebeckite, abolished binding of EGF to the EGFR. This was not due to a direct interaction of fibers with… CONTINUE READING

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