AsSIRTing the DNA damage response.

  title={AsSIRTing the DNA damage response.},
  author={Myriam Gorospe and Rafael de Cabo},
  journal={Trends in cell biology},
  volume={18 2},
In mammalian cells, changes in signaling networks and expressed proteins ensure the adequate detection and management of damaged macromolecules. Here, we review an emergent pathway of maintenance of homeostasis following genotoxic stress. The RNA-binding protein HuR associates with sirtuin (SIRT)1 mRNA and maintains constitutively elevated levels of SIRT1 protein, a deacetylase that elicits a prosurvival function. SIRT1 was recently shown to deacetylate the Nijmegen breakage syndrome (NBS1… CONTINUE READING


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