As(III) and Sb(III) uptake by GlpF and efflux by ArsB in Escherichia coli.

  title={As(III) and Sb(III) uptake by GlpF and efflux by ArsB in Escherichia coli.},
  author={Yu-ling Meng and Zijuan Liu and Barry P. Rosen},
  journal={The Journal of biological chemistry},
  volume={279 18},
The toxicity of the metalloids arsenic and antimony is related to uptake, whereas detoxification requires efflux. In this report we show that uptake of the trivalent inorganic forms of arsenic and antimony into cells of Escherichia coli is facilitated by the aquaglyceroporin channel GlpF and that transport of Sb(III) is catalyzed by the ArsB carrier protein; everted membrane vesicles accumulated Sb(III) with energy supplied by NADH oxidation, reflecting efflux from intact cells. Dissipation of… CONTINUE READING


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