Aryltetralin lignans: chemistry, pharmacology and biotransformations.

@article{Botta2001AryltetralinLC,
  title={Aryltetralin lignans: chemistry, pharmacology and biotransformations.},
  author={Bruno Botta and Giuliano Delle Monache and D. Misiti and Alberto Vitali and Giovanni Zappia},
  journal={Current medicinal chemistry},
  year={2001},
  volume={8 11},
  pages={
          1363-81
        }
}
Podophyllotoxin derivatives like etoposide 7a, etophos 7b, and teniposide 7c are used clinically as potent chemotherapeutic agents for a variety of tumors including small cell lung carcinoma, testicular cancer, and malignant lymphoma. These compounds derived from a series of modifications which converted podophyllotoxin 1a from an entity that interacted with tubulin and blocks mitosis to one that induced a block in late S or early G2 by interacting with topoisomerase II. Synthetic studies on… 
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