Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase.


The degradation of glycosaminoglycans (GAGs) involves a series of exolytic glycosidases and sulfatases that act sequentially on the nonreducing end of the polysaccharide chain. Enzymes have been cloned that catalyze all of the known linkages with the exception of the removal of the 2-O-sulfate group from 2-sulfoglucuronate, which is found in heparan sulfate… (More)
DOI: 10.1021/acschembio.6b01033