Arylsulfatase B Improves Locomotor Function after Mouse Spinal Cord Injury

@inproceedings{Yoo2013ArylsulfataseBI,
  title={Arylsulfatase B Improves Locomotor Function after Mouse Spinal Cord Injury},
  author={Myungsik Yoo and Muntasir Khaled and Kurt M. Gibbs and Jonghun Kim and Bj{\"o}rn Kowalewski and Thomas Dierks and Melitta Schachner},
  booktitle={PloS one},
  year={2013}
}
Bacterial chondroitinase ABC (ChaseABC) has been used to remove the inhibitory chondroitin sulfate chains from chondroitin sulfate proteoglycans to improve regeneration after rodent spinal cord injury. We hypothesized that the mammalian enzyme arylsulfatase B (ARSB) would also enhance recovery after mouse spinal cord injury. Application of the mammalian enzyme would be an attractive alternative to ChaseABC because of its more robust chemical stability and reduced immunogenicity. A one-time… CONTINUE READING

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