Arylpiperazine derivatives as high-affinity 5-HT1A serotonin ligands.

@article{Glennon1988ArylpiperazineDA,
  title={Arylpiperazine derivatives as high-affinity 5-HT1A serotonin ligands.},
  author={Richard A Glennon and Neil Naiman and Robert Allen Lyon and Milt Titeler},
  journal={Journal of medicinal chemistry},
  year={1988},
  volume={31 10},
  pages={
          1968-71
        }
}
Although simple arylpiperazines are commonly considered to be moderately selective for 5-HT1B serotonin binding sites, N4-substitution of such compounds can enhance their affinity for 5-HT1A sites and/or decrease their affinity for 5-HT1B sites. A small series of 4-substituted 1-arylpiperazines was prepared in an attempt to develop agents with high affinity for 5-HT1A sites. Derivatives where the aryl portion is phenyl, 2-methoxyphenyl, or 1-naphthyl, and the 4-substituent is either a… CONTINUE READING
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