Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment.

  title={Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment.},
  author={Denise da Gama Ja{\'e}n Batista and Marcos Meuser Batista and Gabriel Melo de Oliveira and Patr{\'i}cia Borges do Amaral and Joseli Lannes-Vieira and Constança Fel{\'i}cia De Paoli de Carvalho Britto and Angela Cristina Vieira Junqueira and Marli M Lima and Alvaro Jos{\'e} Romanha and Policarpo Ademar Sales J{\'u}nior and Chad E. Stephens and David W Boykin and Maria de Nazar{\'e} Correia Soeiro},
  journal={Antimicrobial agents and chemotherapy},
  volume={54 7},
Chagas' disease, a neglected tropical illness for which current therapy is unsatisfactory, is caused by the intracellular parasite Trypanosoma cruzi. The goal of this work is to investigate the in vitro and in vivo effects of the arylimidamide (AIA) DB766 against T. cruzi. This arylimidamide exhibits strong trypanocidal activity and excellent selectivity for bloodstream trypomastigotes and intracellular amastigotes (Y strain), giving IC(50)s (drug concentrations that reduce 50% of the number of… CONTINUE READING
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