Arylfluoroborates and alkylfluorosilicates as potential PET imaging agents: high-yielding aqueous biomolecular 18F-labeling.

@article{Ting2005ArylfluoroboratesAA,
  title={Arylfluoroborates and alkylfluorosilicates as potential PET imaging agents: high-yielding aqueous biomolecular 18F-labeling.},
  author={Richard Ting and Michael J. Adam and Thomas J. Ruth and David M Perrin},
  journal={Journal of the American Chemical Society},
  year={2005},
  volume={127 38},
  pages={13094-5}
}
Organometalloid compositions of silicon and boron permit rapid, high-yielding, one-step radiolabeling of a covalently linked protein ligand (biotin) under aqueous conditions to give the corresponding alkyltetrafluorosilicates and aryltrifluoroborate salts. Biotin was chosen as a test ligand for protein targeting because of its quantitative interaction with avidin, which in turn allowed us to calculate fluoridation yields that approach 80-100%. The silicate was found to be moderately stable to… CONTINUE READING