Aryl hydrocarbon receptor repressor (AhRR) function revisited: repression of CYP1 activity in human skin fibroblasts is not related to AhRR expression.

@article{Tigges2013ArylHR,
  title={Aryl hydrocarbon receptor repressor (AhRR) function revisited: repression of CYP1 activity in human skin fibroblasts is not related to AhRR expression.},
  author={Julia Tigges and Heike Weighardt and Sandra Wolff and Christine Goetz and Irmgard F{\"o}rster and Zippora Kohne and Ulrike Huebenthal and Hans Friedrich Merk and Josef Abel and Thomas Haarmann-Stemmann and Jean Krutmann and Ellen Fritsche},
  journal={The Journal of investigative dermatology},
  year={2013},
  volume={133 1},
  pages={87-96}
}
The skin reacts to environmental noxae by inducing cytochrome P450 (CYP)-catalyzed reactions via activation of the aryl hydrocarbon receptor (AhR). A drawback of this response is the generation of oxidative stress, which is especially dangerous for postreplicative cells such as dermal fibroblasts, in which damage may accumulate over time. Accordingly, in dermal fibroblasts, CYP1 expression is repressed and it has been proposed that this is due to the AhR repressor (AhRR), which is supposedly… CONTINUE READING