Aryl hydrocarbon receptor plays protective roles in ConA-induced hepatic injury by both suppressing IFN-γ expression and inducing IL-22.

@article{Abe2014ArylHR,
  title={Aryl hydrocarbon receptor plays protective roles in ConA-induced hepatic injury by both suppressing IFN-γ expression and inducing IL-22.},
  author={Hiromi Abe and Akihiro Kimura and Sanae Tsuruta and Tomohiro Fukaya and Ryota Sakaguchi and Rimpei Morita and Takashi Sekiya and Takashi Shichita and Kazuaki Chayama and Yoshiaki Fujii-Kuriyama and Akihiko Yoshimura},
  journal={International immunology},
  year={2014},
  volume={26 3},
  pages={129-37}
}
The aryl hydrocarbon receptor (AhR), a ligand-activated nuclear transcription factor, is known to mediate the toxic and carcinogenic effects of various environmental pollutants, while AhR has been shown to protect animals from various types of tissue injury. ConA-induced hepatitis is known as a mouse model of acute liver injury. Here, we found a protective role of AhR in ConA-induced hepatitis. AhR is induced in the liver during ConA-induced hepatitis, and Ahr (-/-) mice were highly sensitive… CONTINUE READING
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