Aryl hydrocarbon receptor-mediated suppression of GH receptor and Janus kinase 2 expression in mice.

@article{Nukaya2004ArylHR,
  title={Aryl hydrocarbon receptor-mediated suppression of GH receptor and Janus kinase 2 expression in mice.},
  author={Manabu Nukaya and Yoshiki Takahashi and Frank J. Gonzalez and Tetsuya Kamataki},
  journal={FEBS letters},
  year={2004},
  volume={558 1-3},
  pages={96-100}
}
Differential mRNA display revealed that a cDNA encoding the major urinary protein 2 (MUP2) that belongs to the lipocalin superfamily was absent in livers of mice treated with 3-methylcholanthrene (MC). The expression of MUP2 is known to be stimulated by growth hormone (GH), through the GH receptor (GHR), Janus kinase 2 (JAK2) and signal transducer and activator of transcription 5 (STAT5) signal transduction pathway. Since MC is an aryl hydrocarbon receptor (AhR) ligand, the effects of MC… CONTINUE READING