Aryl hydrocarbon receptor-mediated induction of the microRNA-132/212 cluster promotes interleukin-17–producing T-helper cell differentiation

@article{Nakahama2013ArylHR,
  title={Aryl hydrocarbon receptor-mediated induction of the microRNA-132/212 cluster promotes interleukin-17–producing T-helper cell differentiation},
  author={T. Nakahama and Hamza Hanieh and N. Nguyen and I. Chinen and B. Ripley and David Millrine and Soyoung Lee and K. Nyati and P. K. Dubey and K. Chowdhury and Y. Kawahara and T. Kishimoto},
  journal={Proceedings of the National Academy of Sciences},
  year={2013},
  volume={110},
  pages={11964 - 11969}
}
Aryl hydrocarbon receptor (AHR) plays critical roles in various autoimmune diseases such as multiple sclerosis by controlling interleukin-17 (IL-17)–producing T-helper (TH17) and regulatory T cells. Although various transcription factors and cytokines have been identified as key participants in TH17 generation, the role of microRNAs in this process is poorly understood. In this study, we found that expression of the microRNA (miR)-132/212 cluster is up-regulated by AHR activation under TH17… Expand
Toward Understanding the Role of Aryl Hydrocarbon Receptor in the Immune System: Current Progress and Future Trends
  • Hamza Hanieh
  • Medicine, Biology
  • BioMed research international
  • 2014
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