Aryl hydrocarbon receptor-mediated induction of the microRNA-132/212 cluster promotes interleukin-17–producing T-helper cell differentiation

  title={Aryl hydrocarbon receptor-mediated induction of the microRNA-132/212 cluster promotes interleukin-17–producing T-helper cell differentiation},
  author={Taisuke Nakahama and Hamza Hanieh and Nam Nguyen and Ichino Chinen and Barry Ripley and David Millrine and Soyoung Lee and Kishan Kumar Nyati and Praveen Kumar Dubey and Kamal Chowdhury and Yukio Kawahara and Tadamitsu Kishimoto},
  journal={Proceedings of the National Academy of Sciences},
  pages={11964 - 11969}
Aryl hydrocarbon receptor (AHR) plays critical roles in various autoimmune diseases such as multiple sclerosis by controlling interleukin-17 (IL-17)–producing T-helper (TH17) and regulatory T cells. Although various transcription factors and cytokines have been identified as key participants in TH17 generation, the role of microRNAs in this process is poorly understood. In this study, we found that expression of the microRNA (miR)-132/212 cluster is up-regulated by AHR activation under TH17… 

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