Aryl hydrocarbon receptor ligands in cancer: friend and foe

@article{Murray2014ArylHR,
  title={Aryl hydrocarbon receptor ligands in cancer: friend and foe},
  author={Iain Alexander Murray and Andrew D. Patterson and Gary H. Perdew},
  journal={Nature Reviews Cancer},
  year={2014},
  volume={14},
  pages={801-814}
}
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best known for mediating the toxicity and tumour-promoting properties of the carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin, commonly referred to as 'dioxin'. AHR influences the major stages of tumorigenesis — initiation, promotion, progression and metastasis — and physiologically relevant AHR ligands are often formed during disease states or during heightened innate and adaptive immune responses… CONTINUE READING
89 Extracted Citations
183 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 89 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 183 references

Identification of a probiotic bacteria‐derived activator of the aryl hydrocarbon receptor that inhibits colitis

  • S Fukumoto
  • Immunol. Cell Biol
  • 2014

Similar Papers

Loading similar papers…