Aryl hydrocarbon receptor ligands in cancer: friend and foe

  title={Aryl hydrocarbon receptor ligands in cancer: friend and foe},
  author={Iain Alexander Murray and Andrew D. Patterson and Gary H. Perdew},
  journal={Nature Reviews Cancer},
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best known for mediating the toxicity and tumour-promoting properties of the carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin, commonly referred to as 'dioxin'. AHR influences the major stages of tumorigenesis — initiation, promotion, progression and metastasis — and physiologically relevant AHR ligands are often formed during disease states or during heightened innate and adaptive immune responses… CONTINUE READING
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