Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types.

@article{Walisser2005ArylHR,
  title={Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types.},
  author={Jacqueline A. Walisser and Edward Glover and Kalyan Pande and Adam L. Liss and Christopher A. Bradfield},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 49},
  pages={17858-63}
}
The aryl hydrocarbon receptor (AHR) plays a role in three areas of biology that include the adaptive metabolism of xenobiotics, the toxic responses associated with exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), and vascular remodeling of the developing embryo. To test the hypothesis that receptor signaling in different cell types is responsible for these aspects of AHR biology, we generated a conditional Ahr allele where exon 2 is flanked by loxP sites. Through the use of Cre-lox… CONTINUE READING

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