Aryl hydrocarbon receptor control of a disease tolerance defence pathway

@article{Bessede2014ArylHR,
  title={Aryl hydrocarbon receptor control of a disease tolerance defence pathway},
  author={Alban Bessede and Marco Gargaro and Maria Teresa Pallotta and Davide Matino and Giuseppe Servillo and Cinzia Brunacci and Silvio Bicciato and Emilia Maria Cristina Mazza and Antonio Macchiarulo and Carmine Vacca and Rossana Giulietta Iannitti and Luciana Tissi and Claudia Volpi and Maria Laura Belladonna and Ciriana Orabona and Roberta Bianchi and Tobias V Lanz and Michael Platten and Maria Agnese Della Fazia and Danilo Piobbico and Teresa Zelante and Hiroshi Funakoshi and Toshikazu Nakamura and David Gilot and Michael S. Denison and Gilles J Guillemin and James B DuHadaway and George C Prendergast and Richard Metz and Michel Geffard and Louis Boon and Matteo Pirro and Alfonso Iorio and Bernard Veyret and Luigina Romani and Ursula Grohmann and Francesca Fallarino and Paolo Puccetti},
  journal={Nature},
  year={2014},
  volume={511},
  pages={184-190}
}
Disease tolerance is the ability of the host to reduce the effect of infection on host fitness. Analysis of disease tolerance pathways could provide new approaches for treating infections and other inflammatory diseases. Typically, an initial exposure to bacterial lipopolysaccharide (LPS) induces a state of refractoriness to further LPS challenge (endotoxin tolerance). We found that a first exposure of mice to LPS activated the ligand-operated transcription factor aryl hydrocarbon receptor (AhR… CONTINUE READING
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