Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo[a]pyrene.

@article{NDiaye2006ArylHR,
  title={Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo[a]pyrene.},
  author={M. Kabirou N'Diaye and Eric Le Ferrec and Dominique Lagadic-Gossmann and S{\'e}bastien Corre and David Gilot and Val{\'e}rie Lecureur and Patr{\'i}cia A. S. Monteiro and Claudine Rauch and Marie-Dominique Galibert and Olivier Fardel},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 29},
  pages={19906-15}
}
Polycyclic aromatic hydrocarbons (PAHs) are widely distributed immunotoxic environmental contaminants well known to regulate expression of pro-inflammatory cytokines such as interleukine-1beta and tumor necrosis factor-alpha. In the present study, we demonstrated that the chemokine CCL1, notably involved in cardiovascular diseases and inflammatory or allergic processes, constitutes a new molecular target for PAHs. Indeed, exposure to PAHs such as benzo[a]pyrene (BP) markedly increased mRNA… CONTINUE READING