Aryl hydrocarbon receptor (AHR): "pioneer member" of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of "sensors" of foreign and endogenous signals.

@article{Nebert2017ArylHR,
  title={Aryl hydrocarbon receptor (AHR): "pioneer member" of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of "sensors" of foreign and endogenous signals.},
  author={Daniel W. Nebert},
  journal={Progress in lipid research},
  year={2017},
  volume={67},
  pages={
          38-57
        }
}
The basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family comprises many transcription factors, found throughout all three kingdoms of life; bHLH/PAS members "sense" innumerable intracellular and extracellular "signals" - including endogenous compounds, foreign chemicals, gas molecules, redox potential, photons (light), gravity, heat, and osmotic pressure. These signals then initiate downstream signaling pathways involved in responding to that signal. The term "PAS", abbreviation for "per-Arnt… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 19 CITATIONS

Aryl Hydrocarbon Receptor: A New Player of Pathogenesis and Therapy in Cardiovascular Diseases

  • BioMed research international
  • 2018
VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice.

  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2018
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Mechanisms of Developmental Toxicity of Dioxins and Related Compounds

  • International journal of molecular sciences
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 251 REFERENCES

A tryptophan derivative, ITE, enhances liver cell metabolic functions in vitro

  • International journal of molecular medicine
  • 2017
VIEW 12 EXCERPTS
HIGHLY INFLUENTIAL

Emerging roles of resolvins in the D.W

R. R. Ji, Z. Z. Xu, G. Strichartz, C. N. Serhan
  • Nebert Progress in Lipid Research
  • 2017
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Novel proresolving aspirin-triggered DHA pathway.

  • Chemistry & biology
  • 2011
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Regulation of inflammation in cancer by eicosanoids.

  • Prostaglandins & other lipid mediators
  • 2011
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL