Aryl diketoacids (ADK) selectively inhibit duplex DNA-unwinding activity of SARS coronavirus NTPase/helicase.

@article{Lee2009ArylD,
  title={Aryl diketoacids (ADK) selectively inhibit duplex DNA-unwinding activity of SARS coronavirus NTPase/helicase.},
  author={Chaewoon Lee and Jin Moo Lee and Na-Ra Lee and B Jin and Kyoung Jin Jang and Dong-Eun Kim and Yong-Joo Jeong and Youhoon Chong},
  journal={Bioorganic & medicinal chemistry letters},
  year={2009},
  volume={19 6},
  pages={
          1636-8
        }
}
As anti-HCV aryl diketoacids (ADK) are good metal chelators, we anticipated that ADKs might serve as potential inhibitors of SARS CoV (SCV) NTPase/helicase (Hel) by mimicking the binding modes of the bismuth complexes which effectively competes for the Zn(2+) ion binding sites in SCV Hel thereby disrupting and inhibiting both the NTPase and helicase activities. Phosphate release assay and FRET-based assay of the ADK analogues showed that the ADKs selectively inhibit the duplex DNA-unwinding… CONTINUE READING
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