Aryl amide small-molecule inhibitors of microRNA miR-21 function.

  title={Aryl amide small-molecule inhibitors of microRNA miR-21 function.},
  author={Yuta Naro and Meryl Thomas and Matthew D Stephens and Colleen M Connelly and Alexander Deiters},
  journal={Bioorganic & medicinal chemistry letters},
  volume={25 21},
MicroRNAs (miRNAs) are single stranded RNA molecules of ∼22 nucleotides that negatively regulate gene expression. MiRNAs are involved in fundamental cellular processes, such as development, differentiation, proliferation, and survival. MiRNA misregulation has been linked to various human diseases, most notably cancer. MicroRNA-21 (miR-21), a well-established oncomiR, is significantly overexpressed in many types of human cancers, thus rendering miR-21 a potential therapeutic target. Using a… CONTINUE READING
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