Aryl Hydrocarbon Receptor Regulates Distinct Dioxin-Dependent and Dioxin-Independent Gene Batteries

@article{Tijet2006ArylHR,
  title={Aryl Hydrocarbon Receptor Regulates Distinct Dioxin-Dependent and Dioxin-Independent Gene Batteries},
  author={N. Tijet and P. Boutros and I. Moffat and A. Okey and J. Tuomisto and R. Pohjanvirta},
  journal={Molecular Pharmacology},
  year={2006},
  volume={69},
  pages={140 - 153}
}
  • N. Tijet, P. Boutros, +3 authors R. Pohjanvirta
  • Published 2006
  • Biology, Medicine
  • Molecular Pharmacology
  • Conventional biochemical and molecular techniques identified previously several genes whose expression is regulated by the aryl hydrocarbon receptor (AHR). We sought to map the complete spectrum of AHR-dependent genes in male adult liver using expression arrays to contrast mRNA profiles in Ahr-null mice (Ahr–/–) with those in mice with wild-type AHR (Ahr+/+). Transcript profiles were determined both in untreated mice and in mice treated 19 h earlier with 1000 μg/kg 2,3,7,8-tetrachlorodibenzo-p… CONTINUE READING
    325 Citations
    Dioxin-Dependent and Dioxin-Independent Gene Batteries: Comparison of Liver and Kidney in AHR-Null Mice
    • 56
    • PDF
    Patterns of dioxin-altered mRNA expression in livers of dioxin-sensitive versus dioxin-resistant rats
    • 40
    Aryl hydrocarbon receptor-dependence of dioxin's effects on constitutive mouse hepatic cytochromes P450 and growth hormone signaling components.
    • C. Lee, D. Riddick
    • Biology, Medicine
    • Canadian journal of physiology and pharmacology
    • 2012
    • 15
    • Highly Influenced
    • PDF
    Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes.
    • 31
    The mammalian aryl hydrocarbon (Ah) receptor: from mediator of dioxin toxicity toward physiological functions in skin and liver
    • 88
    Aryl Hydrocarbon Receptor-Dependent Induction of Flavin-Containing Monooxygenase mRNAs in Mouse Liver
    • 43
    • PDF
    microRNAs in adult rodent liver are refractory to dioxin treatment.
    • 80
    • PDF

    References

    SHOWING 1-10 OF 45 REFERENCES
    Dioxin-responsive AHRE-II gene battery: identification by phylogenetic footprinting.
    • 99
    ERα-AHR-ARNT Protein-Protein Interactions Mediate Estradiol-dependent Transrepression of Dioxin-inducible Gene Transcription*
    • 180
    • PDF
    Different global gene expression profiles in benzo[a]pyrene-and dioxin-treated vascular smooth muscle cells of AHR-knockout and wild-type mice
    • 55
    Resistance to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity and Abnormal Liver Development in Mice Carrying a Mutation in the Nuclear Localization Sequence of the Aryl Hydrocarbon Receptor*
    • 210
    • Highly Influential
    • PDF
    Expression of genes in the TGF-beta signaling pathway is significantly deregulated in smooth muscle cells from aorta of aryl hydrocarbon receptor knockout mice.
    • 99
    Amelioration of TCDD-induced teratogenesis in aryl hydrocarbon receptor (AhR)-null mice.
    • 215
    • PDF
    Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development.
    • 832
    • PDF
    Toxicological implications of polymorphisms in receptors for xenobiotic chemicals: the case of the aryl hydrocarbon receptor.
    • 122
    The Aryl Hydrocarbon Receptor Displaces p300 from E2F-dependent Promoters and Represses S Phase-specific Gene Expression*
    • 132
    • PDF