Aryl Hydrocarbon Receptor Regulates Distinct Dioxin-Dependent and Dioxin-Independent Gene Batteries

  title={Aryl Hydrocarbon Receptor Regulates Distinct Dioxin-Dependent and Dioxin-Independent Gene Batteries},
  author={N. Tijet and P. Boutros and I. Moffat and A. Okey and J. Tuomisto and R. Pohjanvirta},
  journal={Molecular Pharmacology},
  pages={140 - 153}
  • N. Tijet, P. Boutros, +3 authors R. Pohjanvirta
  • Published 2006
  • Biology, Medicine
  • Molecular Pharmacology
  • Conventional biochemical and molecular techniques identified previously several genes whose expression is regulated by the aryl hydrocarbon receptor (AHR). We sought to map the complete spectrum of AHR-dependent genes in male adult liver using expression arrays to contrast mRNA profiles in Ahr-null mice (Ahr–/–) with those in mice with wild-type AHR (Ahr+/+). Transcript profiles were determined both in untreated mice and in mice treated 19 h earlier with 1000 μg/kg 2,3,7,8-tetrachlorodibenzo-p… CONTINUE READING
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