Aryl Hydrocarbon Receptor Regulates Distinct Dioxin-Dependent and Dioxin-Independent Gene Batteries

@article{Tijet2006ArylHR,
  title={Aryl Hydrocarbon Receptor Regulates Distinct Dioxin-Dependent and Dioxin-Independent Gene Batteries},
  author={Nathalie Tijet and Paul C. Boutros and Ivy D. Moffat and Allan B. Okey and Jouko Tuomisto and Raimo Pohjanvirta},
  journal={Molecular Pharmacology},
  year={2006},
  volume={69},
  pages={140 - 153}
}
Conventional biochemical and molecular techniques identified previously several genes whose expression is regulated by the aryl hydrocarbon receptor (AHR). We sought to map the complete spectrum of AHR-dependent genes in male adult liver using expression arrays to contrast mRNA profiles in Ahr-null mice (Ahr–/–) with those in mice with wild-type AHR (Ahr+/+). Transcript profiles were determined both in untreated mice and in mice treated 19 h earlier with 1000 μg/kg 2,3,7,8-tetrachlorodibenzo-p… Expand
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Dioxin-Dependent and Dioxin-Independent Gene Batteries: Comparison of Liver and Kidney in AHR-Null Mice
TLDR
Transcriptional responses to dioxin exposure in the liver and kidney of wild-type and Ahr-null adult C57BL/6J mice treated with either 2,3,7,8-tetrachlorodibenzo-p-dioxin or corn-oil vehicle were defined and compared, suggesting the presence of a basal AHR gene battery. Expand
Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities
TLDR
The transactivation-domain deletion in dioxin-resistant rats does not abolish global AHR transactivational activity but selectively interferes with expression of subsets of genes that are candidates to mediate or protect from major dioxIn toxicities such as hepatotoxicity, wasting and death. Expand
Patterns of dioxin-altered mRNA expression in livers of dioxin-sensitive versus dioxin-resistant rats
TLDR
To identify specific genes that may be involved in dioxin lethality, changes in liver mRNA levels following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in three strains/ lines of dioxIn-sensitive rats with changes in three diox in-resistant rat strains/lines were compared. Expand
Aryl hydrocarbon receptor-dependence of dioxin's effects on constitutive mouse hepatic cytochromes P450 and growth hormone signaling components.
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It is concluded that AHR activation per se leads to dysregulation of hepatic GH signaling components and suppression of some, but not all, STAT5b target genes. Expand
Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes.
TLDR
Analysis of the effects of AhR silencing on the regulation of various genes targeted by TCDD in primary human hepatocytes and highly-differentiated human hepatoma HepaRG cells indicates that AhR plays a crucial role in both basal and T CDD-induced expression of target genes in human hepatocyte. Expand
The effect of aryl hydrocarbon receptor ligands on the expression of AhR, AhRR, ARNT, Hif1alpha, CYP1A1 and NQO1 genes in rat liver.
TLDR
Results indicate that binding of the ligands to AhR up-regulates the mRNA transcription not only of CYP1A1 and NQO1, but also of AhR itself, which depends on the potency of xenobiotic metabolizing enzymes inducer. Expand
The mammalian aryl hydrocarbon (Ah) receptor: from mediator of dioxin toxicity toward physiological functions in skin and liver
TLDR
This work focuses on skin and liver to facilitate discussion of mechanisms linking phenotypes and AhR-modulated genotypes, and efforts elucidating the pathway toward identification of physiological functions of the AhR remain challenging and promising. Expand
Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR).
TLDR
A rank-based test was used to identify factors that activate or suppress AhR in an annotated mouse liver/mouse primary hepatocyte gene expression database of ∼ 1850 comparisons and resulted in a balanced accuracy of 95%. Expand
Aryl Hydrocarbon Receptor-Dependent Induction of Flavin-Containing Monooxygenase mRNAs in Mouse Liver
TLDR
Ch Chromatin immunoprecipitation demonstrated recruitment of AHR and aryl hydrocarbon nuclear translocator proteins to Fmo3 regulatory regions, suggesting that induction by TCDD is a primary AHR-mediated event. Expand
microRNAs in adult rodent liver are refractory to dioxin treatment.
TLDR
It is hypothesized that microRNAs (miRNAs), which have emerged as powerful negative regulators of mRNA levels in several systems, might be responsible for mRNA downregulation in dioxin/AHR pathways, and it is unlikely that mRNA down regulation by dioxins is mediated by miRNAs, nor are mi RNAs likely to play a significant role in doxin toxicity in adult rodent liver. Expand
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