Aryl Hydrocarbon Receptor Deficiency Protects Mice from Diet-induced Adiposity and Metabolic Disorders through Increased Energy Expenditure

@inproceedings{Xu2015ArylHR,
  title={Aryl Hydrocarbon Receptor Deficiency Protects Mice from Diet-induced Adiposity and Metabolic Disorders through Increased Energy Expenditure},
  author={Can-Xin Xu and Chun Wang and Z Zhang and Cassie Jaeger and Stacey L. Krager and Kathleen M. Bottum and Jianghua Liu and Duan-fang Liao and Shelley A. Tischkau},
  booktitle={International Journal of Obesity},
  year={2015}
}
Background/Objectives:Epidemics of obesity and diabetes are escalating. High-calorie/high-fat food is a major cause for these global health issues, but molecular mechanisms underlying high-fat, diet-induced obesity are still not well understood. The aryl hydrocarbon receptor (AhR), a transcription factor that acts as a xenobiotic sensor, mediates environmental toxicant-induced obesity, insulin resistance and development of diabetes. AhR also influences lipid metabolism and diet-induced obesity… CONTINUE READING
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