Arx is required for normal enteroendocrine cell development in mice and humans.

@article{Du2012ArxIR,
  title={Arx is required for normal enteroendocrine cell development in mice and humans.},
  author={Aiping Du and Kyle W. McCracken and Erik R. Walp and Natalie A. Terry and Thomas J. Klein and Annie Han and James M Wells and Catherine Lee May},
  journal={Developmental biology},
  year={2012},
  volume={365 1},
  pages={175-88}
}
Enteroendocrine cells of the gastrointestinal (GI) tract play a central role in metabolism, digestion, satiety and lipid absorption, yet their development remains poorly understood. Here we show that Arx, a homeodomain-containing transcription factor, is required for the normal development of mouse and human enteroendocrine cells. Arx expression is detected in a subset of Neurogenin3 (Ngn3)-positive endocrine progenitors and is also found in a subset of hormone-producing cells. In mice, removal… CONTINUE READING