Artificial opsonin enhances bacterial phagocytosis, oxidative burst and chemokine production by human neutrophils.

@article{Katzenmeyer2017ArtificialOE,
  title={Artificial opsonin enhances bacterial phagocytosis, oxidative burst and chemokine production by human neutrophils.},
  author={Kristy N Katzenmeyer and Luisa Mayorga Szott and James D Bryers},
  journal={Pathogens and disease},
  year={2017},
  volume={75 6}
}
Here, we describe the application of an 'artificial opsonin' to stimulate the innate immune response against Gram-positive bacteria. The artificial opsonin comprises a poly(L-lysine)-graft-poly(ethylene glycol) backbone displaying multiple copies of vancomycin and human IgG-Fc. The vancomycin targets bacteria by recognizing d-Ala-d-Ala-terminated peptides present in the bacterial cell wall. The human IgG-Fc antibody fragments serve as phagocyte recognition moieties that recognize the Fcγ cell… CONTINUE READING
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