Artificial microvascular network: a new tool for measuring rheologic properties of stored red blood cells

@article{Burns2011ArtificialMN,
  title={Artificial microvascular network: a new tool for measuring rheologic properties of stored red blood cells},
  author={Jennie M. Burns and Xiaoxi Yang and Omid Forouzan and Jose M Sosa and Sergey S. Shevkoplyas},
  journal={Transfusion},
  year={2011},
  volume={52}
}
BACKGROUND: The progressive deterioration of red blood cell (RBC) rheologic properties during refrigerated storage may reduce the clinical efficacy of transfusion of older units. 
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21 Citations
Background Citations
3
Methods Citations
5
Results Citations
1

21 Citations

Dynamics of shape recovery by stored red blood cells during washing at the single cell level

This work investigated how washing (known to positively affect RBC properties) changes morphology of individual RBCs at the single‐cell level.

Concurrent Assessment of Deformability and Adhesiveness of Sickle Red Blood Cells by Measuring Perfusion of an Adhesive Artificial Microvascular Network

Overall, these findings suggest the potential utility of the adhesive AMVN device for evaluating the effect of novel curative and palliative therapies on the hemorheological status of SCD patients during clinical trials and in post-market clinical practice.

Development of a flow standard to enable highly reproducible measurements of deformability of stored red blood cells in a microfluidic device

A new method to standardize and improve reproducibility of the RBC deformability measurements using one of a number of microfluidic devices with capillary‐like microchannels is described.

Hypoxic storage of donor red cells preserves deformability after exposure to plasma from adults with sickle cell disease

This work tested the hypotheses that the donor RBCs exposed to the plasma of patients in crisis would have lower deformability and higher hemolysis than those exposed to non‐crisis plasma, and hypoxic storage, compared to standard storage, of donor R BCs could preserve deformable and reduce hemolytics.

Microfluidic capillary networks are more sensitive than ektacytometry to the decline of red blood cell deformability induced by storage

Test data suggest that capillary networks are significantly more sensitive to both the overall storage-induced decline of RBC deformability, and to the differences between the two storage conditions, than ektacytometry.

Temporal sequence of the human RBCs' vesiculation observed in nano-scale with application of AFM and complementary techniques.

Blood rheology biomarkers in sickle cell disease

A comprehensive panel of rheological biomarkers, their clinical uses, and the technologies used to obtain them are described, which could significantly accelerate the development, optimization, and clinical translation of novel therapies for SCD.

Changes in Erythrocyte Morphology at Initiation of Cardiopulmonary Bypass Without Blood Transfusion Were Not Associated With Less Deformability During Cardiac Surgery.

Morphological changes at initiation of CPB are considered potentially reversible transformations without loss of the membrane surface area and do not have a significant effect on the DImax; a decrease in deformability likely is due to transfusion of stored RBCs.

Effects of hypoxic storage on the efficacy of gamma irradiation in abrogating lymphocyte proliferation and on the quality of gamma‐irradiated red blood cells in additive solution 3

The objectives of the study were to investigate the effects of hypoxia on gamma irradiation‐induced inhibition of LP and on the in vitro properties of RBCs.

Albumin reverses the echinocytic shape transformation of stored erythrocytes.

In conclusion, albumin has the capacity to reverse echinocytosis generated by RBC storage, which may improve the quality of RBC units stored for longer periods of time.

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