Artificial engineering of secondary lymphoid organs.

  title={Artificial engineering of secondary lymphoid organs.},
  author={Jonathan K H Tan and Takeshi Watanabe},
  journal={Advances in immunology},
Secondary lymphoid organs such as spleen and lymph nodes are highly organized immune structures essential for the initiation of immune responses. They display distinct B cell and T cell compartments associated with specific stromal follicular dendritic cells and fibroblastic reticular cells, respectively. Interweaved through the parenchyma is a conduit system that distributes small antigens and chemokines directly to B and T cell zones. While most structural aspects between lymph nodes and… CONTINUE READING