Artificial chromosomes: ideal vectors?

@article{Brown2000ArtificialCI,
  title={Artificial chromosomes: ideal vectors?},
  author={William R. A. Brown and Patrick J. Mee and M Hong Shen},
  journal={Trends in biotechnology},
  year={2000},
  volume={18 5},
  pages={218-23}
}
Artificial chromosomes are DNA molecules of predictable structure, which are assembled in vitro from defined constituents that behave with the properties of natural chromosomes. Artificial chromosomes were first assembled in budding yeast and have since been useful in many aspects of yeast genetics. Several attempts have been made at building artificial chromosomes in mammals, although these have been met with limited success. Consequently, mini-chromosomes of defined structure have been… CONTINUE READING

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