Artificial beta-cell application in two cases of insulinoma: a different pattern in beta-cell adenoma and carcinoma.

@article{Brunetti1979ArtificialBA,
  title={Artificial beta-cell application in two cases of insulinoma: a different pattern in beta-cell adenoma and carcinoma.},
  author={Paolo Brunetti and Fausto Santeusanio and Adolfo Puxeddu and M. Massi-Benedetti and Giuseppe Calabrese and Gabriella Angeletti and Antonino Bueti and Luciano Scionti and Michele De Angelis},
  journal={Hormone and metabolic research. Supplement series},
  year={1979},
  volume={8},
  pages={
          173-7
        }
}
With the aid of an artificial beta-cell (Biostator, Miles Laboratories Inc.), a different metabolic and biological pattern of behaviour was observed in benign versus malignant insulinoma. In the patient with beta-cell adenoma but not in the one with carcinoma, plasma insulin concentrations decreased promptly and markedly, and blood glucose increased during diazoxide and somatostatin infusion. Moreover, only in the adenoma patient was glucose need characterized by a circadian rhythm with the… CONTINUE READING