Artificial activation of toxin-antitoxin systems as an antibacterial strategy.

@article{Williams2012ArtificialAO,
  title={Artificial activation of toxin-antitoxin systems as an antibacterial strategy.},
  author={Julia J. Williams and Paul J. Hergenrother},
  journal={Trends in microbiology},
  year={2012},
  volume={20 6},
  pages={291-8}
}
Toxin-antitoxin (TA) systems are unique modules that effect plasmid stabilization via post-segregational killing of the bacterial host. The genes encoding TA systems also exist on bacterial chromosomes, and it has been speculated that these are involved in a variety of cellular processes. Interest in TA systems has increased dramatically over the past 5 years as the ubiquitous nature of TA genes on bacterial genomes has been revealed. The exploitation of TA systems as an antibacterial strategy… CONTINUE READING