Artificial Selection for Increased Wheel-Running Behavior in House Mice

@article{Swallow1998ArtificialSF,
  title={Artificial Selection for Increased Wheel-Running Behavior in House Mice},
  author={John G. Swallow and Patrick A. Carter and Theodore Garland},
  journal={Behavior Genetics},
  year={1998},
  volume={28},
  pages={227-237}
}
Replicated within-family selection for increased voluntary wheel running in outbred house mice (Mus domesticus; Hsd:ICR strain) was applied with four high-selected and four control lines (10 families/line). Mice were housed individually with access to activity wheels for a period of 6 days, and selection was based on the mean number of revolutions run on days 5 and 6. Prior to selection, heritabilities of mean revolutions run per day (rev/day), average running velocity (rpm), and number of… 

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References

SHOWING 1-10 OF 34 REFERENCES
Effects of voluntary activity and genetic selection on aerobic capacity in house mice (Mus domesticus).
TLDR
The results suggest the existence of a possible genetic correlation between voluntary activity levels (behavior) and aerobic capacity (physiology), and nests two-way analysis of covariance demonstrated that both genetic selection history and access to wheels had significant positive effects on VO2max.
Replicated selection for body weight in mice.
TLDR
The variation between the replicates was ascribed mainly to random drift, which may seriously influence the conclusions about the realized heritability and the asymmetry of response that would be drawn from a single experiment with the population size of one of these replicates.
QUANTITATIVE GENETICS OF SPRINT RUNNING SPEED AND SWIMMING ENDURANCE IN LABORATORY HOUSE MICE (MUS DOMESTICUS)
TLDR
It is predicted that artificial selection for increased locomotor speed in these mice would result in a decrease in endurance, but no change in body mass, which could lead to a better understanding of the physiological mechanisms leading to trade‐offs in aspects of locomotor abilities.
Exercise physiology of wild and random-bred laboratory house mice and their reciprocal hybrids.
TLDR
In general, the behavioral and/or whole organisms performance traits showed greater differences than the lower-level traits; thus, during the domestication of house mice, behavior may have evolved more rapidly than physiology.
Response to divergent selection for nesting behavior in Mus musculus.
TLDR
Replicated bidirectional selection for nest-building behavior in Mus musculus yielded an eight-fold difference between high and low lines after 15 generations of selection, and inbreeding could account for average decreases in the fertility traits, but there was also a correlated response to selection.
Open-field behavior in mice: Selection response and situational generality
TLDR
Change in activity as a function of selection during the last five generations was found to be somewhat less than that during the first five generations, although the correlated response in open-field defecation has continued.
Exercise increases average longevity of female rats despite increased food intake and no growth retardation.
TLDR
Results show that exercise improves average longevity of rats independent of decreased availability of energy for cell proliferation and growth, and provide evidence that an increase in food intake is not harmful when balanced by a increase in energy expenditure.
Heritability of locomotor play in house mice, Mus domesticus
Individual variation in locomotor behavior and maximal oxygen consumption in mice
Response to 30 generations of selection for open-field activity in laboratory mice
TLDR
Since the selection experiment is replicated, other variables which are found to be reliably different among the high, control, and low lines are likely to be causally related to open-field activity; thus these selected lines of mice may be of use to other investigators.
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