Artificial, non-antibody binding proteins for pharmaceutical and industrial applications.

@article{Hey2005ArtificialNB,
  title={Artificial, non-antibody binding proteins for pharmaceutical and industrial applications.},
  author={Thomas Hey and Erik Fiedler and Rainer Rudolph and Markus Fiedler},
  journal={Trends in biotechnology},
  year={2005},
  volume={23 10},
  pages={514-22}
}
Using combinatorial chemistry to generate novel binding molecules based on protein frameworks ('scaffolds') is a concept that has been strongly promoted during the past five years in both academia and industry. Non-antibody recognition proteins derive from different structural families and mimic the binding principle of immunoglobulins to varying degrees. In addition to the specific binding of a pre-defined target, these proteins provide favourable characteristics such as robustness, ease of… CONTINUE READING