Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis.

@article{Loeser2005ArticularCE,
  title={Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis.},
  author={Richard F. Loeser and Raghunatha R Yammani and Cathy S Carlson and Hong Chen and Ada A Cole and Hee-Jeong Im and Laura S. Bursch and Shirley ShiDu Yan},
  journal={Arthritis and rheumatism},
  year={2005},
  volume={52 8},
  pages={2376-85}
}
OBJECTIVE The receptor for advanced glycation end products (RAGE) binds multiple ligands, including S100 proteins, high mobility group box chromosomal protein 1 (HMGB-1), and AGEs, all of which are present in articular cartilage. Stimulation of RAGE signaling can lead to MAP kinase activation and increased NF-kappaB activity. The objective of the present study was to determine if chondrocytes express functional RAGE. METHODS The presence of chondrocyte RAGE was analyzed by… CONTINUE READING

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