Articular chondrocytes express connexin 43 hemichannels and P2 receptors – a putative mechanoreceptor complex involving the primary cilium?

@article{Knight2009ArticularCE,
  title={Articular chondrocytes express connexin 43 hemichannels and P2 receptors – a putative mechanoreceptor complex involving the primary cilium?},
  author={M. Knight and S. McGlashan and M. Garcia and C. Jensen and C. Poole},
  journal={Journal of Anatomy},
  year={2009},
  volume={214}
}
Mechanical loading is essential for the health and homeostasis of articular cartilage, although the fundamental mechanotransduction pathways are unclear. Previous studies have demonstrated that cyclic compression up‐regulates proteoglycan synthesis via an intracellular Ca2+ signalling pathway, mediated by the release of ATP. However, the mechanism(s) of ATP release has not been elucidated. The present study examines expression of the putative mechanosensitive ATP‐release channel, connexin 43… Expand
Cyclic loading opens hemichannels to release ATP as part of a chondrocyte mechanotransduction pathway
  • Mariana García, M. Knight
  • Chemistry, Medicine
  • Journal of orthopaedic research : official publication of the Orthopaedic Research Society
  • 2010
Primary cilia mediate mechanotransduction through control of ATP‐induced Ca2+ signaling in compressed chondrocytes
  • A. Wann, N. Zuo, +4 authors M. Knight
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2012
P2X7 ionotropic receptor is functionally expressed in rabbit articular chondrocytes and mediates extracellular ATP cytotoxicity
Shifting Paradigms on the Role of Connexin43 in the Skeletal Response to Mechanical Load
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