Articular chondrocytes and mesenchymal stem cells seeded on biodegradable scaffolds for the repair of cartilage in a rat osteochondral defect model.

@article{Dahlin2014ArticularCA,
  title={Articular chondrocytes and mesenchymal stem cells seeded on biodegradable scaffolds for the repair of cartilage in a rat osteochondral defect model.},
  author={Rebecca L. Dahlin and Lucas A. Kinard and Johnny Lam and Clark J. Needham and Steven Lu and F. Kurtis Kasper and Antonios G Mikos},
  journal={Biomaterials},
  year={2014},
  volume={35 26},
  pages={7460-9}
}
This work investigated the ability of co-cultures of articular chondrocytes and mesenchymal stem cells (MSCs) to repair articular cartilage in osteochondral defects. Bovine articular chondrocytes and rat MSCs were seeded in isolation or in co-culture onto electrospun poly(ɛ-caprolactone) (PCL) scaffolds and implanted into an osteochondral defect in the trochlear groove of 12-week old Lewis rats. Additionally, a blank PCL scaffold and untreated defect were investigated. After 12 weeks, the… CONTINUE READING
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