Articular cartilage repair by genetically modified bone marrow aspirate in sheep

  title={Articular cartilage repair by genetically modified bone marrow aspirate in sheep},
  author={Alan Ivkovi{\'c} and Arnulf Pascher and Damir Hudetz and Dra{\vz}en Mati{\vc}i{\'c} and Mislav Jeli{\'c} and Sally Dickinson and Marko Lopari{\'c} and Miroslav Ha{\vs}pl and Reinhard Windhager and Marko Pe{\vc}ina},
  journal={Gene Therapy},
Bone marrow presents an attractive option for the treatment of articular cartilage defects as it is readily accessible, it contains mesenchymal progenitor cells that can undergo chondrogenic differentiation and, once coagulated, it provides a natural scaffold that contains the cells within the defect. This study was performed to test whether an abbreviated ex vivo protocol using vector-laden, coagulated bone marrow aspirates for gene delivery to cartilage defects may be feasible for clinical… CONTINUE READING


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