Corpus ID: 35870658

Article in press-uncorrected proof The untility of six over-the-counter ( home ) pregnancy tests

  title={Article in press-uncorrected proof The untility of six over-the-counter ( home ) pregnancy tests},
  author={Laurence A. Cole},
Background: The home pregnancy market is rapidly evolving. It has moved from detection of pregnancy on the day of missed menstrual bleeding, to detection claims 4 days prior. It is moving from all manual tests to digital tests, with a monitor reading the bands and informing women they are pregnant. A thorough study is needed to investigate the validity of claims and evolving usefulness of devices. Methods: Studies were proposed to examine the sensitivity and specificity of home tests and their… Expand

Tables from this paper


Sensitivity of over-the-counter pregnancy tests: comparison of utility and marketing messages.
The majority of products tested were found to detect only a small percentage of pregnancies on the first day of a missed menstrual period, and pharmacists should advise consumers to be cautious in interpreting test results. Expand
Accuracy of home pregnancy tests at the time of missed menses.
The utility of home pregnancy tests (HPTs) is questioned and Clinicians need to be aware of the limitations of current HPT brands. Expand
Background hCG in non-pregnant individuals: need for more sensitive point-of-care and over-the-counter pregnancy tests.
A large clinical trial is needed examining background hCG (hCG levels in absence of pregnancy) and determining whether sensitivities can be improved to avoid false negative detection, and whether a test with sensitivity 1.2-5 IU/L may be appropriate for urine pregnancy testing. Expand
Natural limits of pregnancy testing in relation to the expected menstrual period.
The highest possible screening sensitivity for an hCG-based pregnancy test is estimated to be 90% (95% confidence interval [CI], 84%-94%) on the first day of the missed period, while an even larger percentage of clinical pregnancies may be undetected by current test kits on this day, given their reported assay properties and other practical limitations. Expand
The normal variabilities of the menstrual cycle.
The data confirm epidemiological studies on menstrual cycle length and variability and hormonal studies on timing of the ovulatory window and its variability and provide guidelines for differentiating normal and problem menstrual cycles. Expand
Qualitative point-of-care and over-the-counter urine hCG devices differentially detect the hCG variants of early pregnancy.
Both OTC and POC devices are capable of detecting hCG concentrations in early pregnancy urine, and OTC devices demonstrated better analytical sensitivity relative to Poc devices. Expand
Levels of urinary human chorionic gonadotrophin (hCG) following conception and variability of menstrual cycle length in a cohort of women attempting to conceive.
Evaluating concentrations of hCG relative to LH surge results in consistent increases between women up to 21 days after conception, and urinary hCG concentration can be used to accurately estimate time since conception. Expand
Gestational trophoblastic diseases: 2. Hyperglycosylated hCG as a reliable marker of active neoplasia.
The data presented appear sufficient to encourage the adoption of hCG-H as a tumor marker in trophoblastic disease and is a 100% sensitive marker for discriminating quiescent GTD from active GTN/choriocarcinoma. Expand
Carbohydrate and peptide structure of the α- and β-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma
The evidence of alternative or “hyperbranched” glycoforms on both α- and β-subunits, seen at low levels in normal pregnancy and at increased or even predominant levels in malignant disease, suggests alternative substrate accessibility for Golgi processing enzymes, α1,6fucosyl transferase andN-acetylglucosaminyltransferase IV. Expand