Arthroplasty membrane-derived fibroblasts directly induce osteoclast formation and osteolysis in aseptic loosening.

Abstract

PURPOSE Both macrophages and fibroblasts are the main cell types found in periprosthetic tissues surrounding failed joint arthroplasties. These fibroblasts are known to express RANKL and to produce TNFalpha, factors which promote osteoclast formation and bone resorption. In this study we have analysed the role that arthroplasty membrane-derived fibroblasts… (More)

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@article{Sabokbar2005ArthroplastyMF, title={Arthroplasty membrane-derived fibroblasts directly induce osteoclast formation and osteolysis in aseptic loosening.}, author={Afsie Sabokbar and Ichiro Itonaga and Si Sun and Osami Kudo and Nicholas Anthony Athanasou}, journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society}, year={2005}, volume={23 3}, pages={511-9} }