Arthroplasty for ochronotic arthritis: no failure of 11 replacements in 3 patients followed 6-12 years.


BACKGROUND Alkaptonuria is a rare single-gene disorder characterized by black pigmentation of cartilage and other connective tissues. Premature degenerative arthritis affects the large joints in many of these of patients. Medical treatment is limited to a protein-restricted diet (phenylalanine and tyrosine) with surgery reserved for end-stage joint disease… (More)


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