Arthritogenic alphaviral infection perturbs osteoblast function and triggers pathologic bone loss.

@article{Chen2014ArthritogenicAI,
  title={Arthritogenic alphaviral infection perturbs osteoblast function and triggers pathologic bone loss.},
  author={Weiqiang Chen and Suan-Sin Foo and Nestor E. Rulli and Adam Taylor and Kuo-Ching Sheng and Lara J Herrero and Belinda L. Herring and Brett A. Lidbury and Rachel W. Li and Nicole C. Walsh and Natalie A Sims and Paul N. Smith and Suresh Mahalingam},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 16},
  pages={6040-5}
}
Arthritogenic alphaviruses including Ross River virus (RRV), Sindbis virus, and chikungunya virus cause worldwide outbreaks of musculoskeletal disease. The ability of alphaviruses to induce bone pathologies remains poorly defined. Here we show that primary human osteoblasts (hOBs) can be productively infected by RRV. RRV-infected hOBs produced high levels of inflammatory cytokine including IL-6. The RANKL/OPG ratio was disrupted in the synovial fluid of RRV patients, and this was accompanied by… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 20 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Reply to Noret et al

  • Z Her
  • J Infect Dis
  • 2012

Similar Papers

Loading similar papers…