Arthritis induced in rats with nonimmunogenic adjuvants as models for rheumatoid arthritis.

@article{Holmdahl2001ArthritisII,
  title={Arthritis induced in rats with nonimmunogenic adjuvants as models for rheumatoid arthritis.},
  author={Rikard Holmdahl and Johnny C. Lorentzen and S Lu and Peter Olofsson and Lena Wester and Jens Olof Holmberg and U. Pettersson},
  journal={Immunological reviews},
  year={2001},
  volume={184},
  pages={184-202}
}
Rat models are useful for studies of the pathogenesis of rheumatoid arthritis (RA) since rats are extraordinarily sensitive to induction of arthritis with adjuvants. Injection of not only the classical complete Freund's adjuvant but also mineral oil without mycobacteria and pure adjuvants such as pristane and squalene, induce severe arthritis in many rat strains. Models like pristane-induced arthritis in rats are optimal models for RA since they fulfill the RA criteria including a chronic… CONTINUE READING
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